The first cryptocurrency to capture the public imagination was Bitcoin, which was launched in 2009 by an individual or group known under the pseudonym, Satoshi Nakamoto. As of February 2019, there were over 17.53 million bitcoins in circulation with a total market value of around $63 billion (although the market price of bitcoin can fluctuate quite a bit). Bitcoin's success has spawned a number of competing cryptocurrencies, known as "altcoins" such as Litecoin, Namecoin and Peercoin, as well as Ethereum, EOS, and Cardano. Today, there are literally thousands of cryptocurrencies in existence, with an aggregate market value of over $120 billion (Bitcoin currently represents more than 50% of the total value).

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Ripple (XRP) is an independent digital asset that is native to the Ripple Consensus Ledger. With proven governance and the fastest transaction confirmation of its kind, XRP is said to be the most efficient settlement option for financial institutions and liquidity providers seeking global reach, accessibility and fast settlement finality for interbank flows.
Bitcoin Cash trades on digital currency exchanges including Bitstamp, Coinbase, Gemini, Kraken, and ShapeShift using the Bitcoin Cash name and the BCH ticker symbol for the cryptocurrency. A few other exchanges use the BCC ticker symbol, though BCC is commonly used for Bitconnect. On 26 March 2018, OKEX removed all Bitcoin Cash trading pairs except for BCH/BTC, BCH/ETH and BCH/USDT due to "inadequate liquidity". As of May 2018, daily transaction numbers for Bitcoin Cash are about one-tenth of those of bitcoin. By November 2017 the value of Bitcoin Cash, which had been as high as $900, had fallen to around $300, much of that due to people who had originally held Bitcoin selling off the Bitcoin Cash they received at the hard fork.

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^ Park KS, Raffeld M, Moon YW, Xi L, Bianco C, Pham T, Lee LC, Mitsudomi T, Yatabe Y, Okamoto I, Subramaniam D, Mok T, Rosell R, Luo J, Salomon DS, Wang Y, Giaccone G (Jul 2014). "CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance". The Journal of Clinical Investigation. 124 (7): 3003–15. doi:10.1172/JCI73048. PMC 4071378. PMID 24911146.

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Bitcoin Cash trades on digital currency exchanges including Bitstamp, Coinbase, Gemini, Kraken, and ShapeShift using the Bitcoin Cash name and the BCH ticker symbol for the cryptocurrency. A few other exchanges use the BCC ticker symbol, though BCC is commonly used for Bitconnect. On 26 March 2018, OKEX removed all Bitcoin Cash trading pairs except for BCH/BTC, BCH/ETH and BCH/USDT due to "inadequate liquidity". As of May 2018, daily transaction numbers for Bitcoin Cash are about one-tenth of those of bitcoin. By November 2017 the value of Bitcoin Cash, which had been as high as $900, had fallen to around $300, much of that due to people who had originally held Bitcoin selling off the Bitcoin Cash they received at the hard fork.

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Central to the appeal and function of Bitcoin is the blockchain technology it uses to store an online ledger of all the transactions that have ever been conducted using bitcoins, providing a data structure for this ledger that is exposed to a limited threat from hackers and can be copied across all computers running Bitcoin software. Every new block generated must be verified by the ledgers of each user on the market, making it almost impossible to forge transaction histories. Many experts see this blockchain as having important uses in technologies such as online voting and crowdfunding, and major financial institutions such as JPMorgan Chase see potential in cryptocurrencies to lower transaction costs by making payment processing more efficient. However, because cryptocurrencies are virtual and do not have a central repository, a digital cryptocurrency balance can be wiped out by a computer crash if a backup copy of the holdings does not exist, or if somebody simply loses their private keys. At the same time, there is no central authority, government, or corporation that has access to your funds or your personal information.

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Central to the appeal and function of Bitcoin is the blockchain technology it uses to store an online ledger of all the transactions that have ever been conducted using bitcoins, providing a data structure for this ledger that is exposed to a limited threat from hackers and can be copied across all computers running Bitcoin software. Every new block generated must be verified by the ledgers of each user on the market, making it almost impossible to forge transaction histories. Many experts see this blockchain as having important uses in technologies such as online voting and crowdfunding, and major financial institutions such as JPMorgan Chase see potential in cryptocurrencies to lower transaction costs by making payment processing more efficient. However, because cryptocurrencies are virtual and do not have a central repository, a digital cryptocurrency balance can be wiped out by a computer crash if a backup copy of the holdings does not exist, or if somebody simply loses their private keys. At the same time, there is no central authority, government, or corporation that has access to your funds or your personal information.

A cryptocurrency is a digital or virtual currency that uses cryptography for security. A cryptocurrency is difficult to counterfeit because of this security feature. Many cryptocurrencies are decentralized systems based on blockchain technology, a distributed ledger enforced by a disparate network of computers. A defining feature of a cryptocurrency, and arguably its biggest allure, is its organic nature; it is not issued by any central authority, rendering it theoretically immune to government interference or manipulation.

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Cryptocurrencies are systems that allow for the secure payments of online transactions that are denominated in terms of a virtual "token," representing ledger entries internal to the system itself. "Crypto" refers to the fact that various encryption algorithms and cryptographic techniques, such as elliptical curve encryption, public-private key pairs, and hashing functions, are employed.

^ Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G (Aug 2010). "A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease". Stem Cells. 28 (8): 1326–37. doi:10.1002/stem.458. PMID 20641036.

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To keep the block generation time equal to ten minutes on average, both Bitcoin and Bitcoin Cash use an algorithm adjusting the mining difficulty parameter. This algorithm is called the difficulty adjustment algorithm (DAA). Originally, both Bitcoin and Bitcoin Cash used the same difficulty adjustment algorithm, adjusting the mining difficulty parameter every 2016 blocks. Since 1 August 2017, Bitcoin Cash also used an addition to the DAA, called an Emergency Difficulty Adjustment (EDA) algorithm. EDA was used alongside the original DAA and it was designed to decrease the mining difficulty of Bitcoin Cash by 20%, if the time difference between 6 successive blocks was greater than 12 hours.[36]

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In the field of road transport, an interchange is a road junction that uses grade separation, and typically one or more ramps, to permit traffic on at least one highway to pass through the junction without interruption from other crossing traffic streams. It differs from a standard intersection, where roads cross at grade. Interchanges are almost always used when at least one road is a controlled-access highway (freeway or motorway) or a limited-access divided highway (expressway), though they are sometimes used at junctions between surface streets. 

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Bitcoin Cash trades on digital currency exchanges including Bitstamp,[30] Coinbase,[31] Gemini,[32] Kraken,[33] Bitfinex, and ShapeShift using the Bitcoin Cash name and the BCH ticker symbol for the cryptocurrency. On 26 March 2018, OKEx removed all Bitcoin Cash trading pairs except for BCH/BTC, BCH/ETH and BCH/USDT due to "inadequate liquidity".[5] As of May 2018, daily transaction numbers for Bitcoin Cash are about one-tenth of those of bitcoin.[5]

Bitcoin Cash trades on digital currency exchanges including Bitstamp, Coinbase, Gemini, Kraken, and ShapeShift using the Bitcoin Cash name and the BCH ticker symbol for the cryptocurrency. A few other exchanges use the BCC ticker symbol, though BCC is commonly used for Bitconnect. On 26 March 2018, OKEX removed all Bitcoin Cash trading pairs except for BCH/BTC, BCH/ETH and BCH/USDT due to "inadequate liquidity". As of May 2018, daily transaction numbers for Bitcoin Cash are about one-tenth of those of bitcoin. By November 2017 the value of Bitcoin Cash, which had been as high as $900, had fallen to around $300, much of that due to people who had originally held Bitcoin selling off the Bitcoin Cash they received at the hard fork.

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A partial-Y interchange is used where one highway terminates at another highway with the same general directional alignment (usually a maximum of sixty degrees). The trunk of the terminating highway merges with the trunk of the continuous highway; vehicles traveling into the interchange may only exit traveling in the same direction. This type of interchange is often used for bypass routes, and is named for the shape the two highways' confluence makes when drawn on a map, creating a lower-case "y". An example exists at the western terminus of M-14 in Michigan. Another example is the interchange between I-15 and I-84 in Ogden, Utah

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A variation of the windmill, called the diverging windmill, increases capacity by altering the direction of traffic flow of the interchanging highways, making the connecting ramps much more direct. There also is a hybrid interchange somewhat like the diverging windmill in which left turn exits merge on the left, but it differs in that the left turn exits use left directional ramps.

The parclo is a safer modification of the cloverleaf design. Depending on the number of ramps used, they take up a moderate to large amount of land and are typically inexpensive to build. Parclos with more ramps have a greater capacity and efficiency than parclos with fewer ramps. Parclos are sometimes called a folded diamonds when only four ramps, in two quadrants, are used. If the loop ramps are constructed opposite or mirrored along the highway, weaving is avoided. Cloverleaf interchanges that involve a non-highway can be changed to parclos without too much reconstruction. Although the interchange's capacity is reduced, weaving is eliminated, increasing the safety and efficiency of the interchange.

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^ Park KS, Raffeld M, Moon YW, Xi L, Bianco C, Pham T, Lee LC, Mitsudomi T, Yatabe Y, Okamoto I, Subramaniam D, Mok T, Rosell R, Luo J, Salomon DS, Wang Y, Giaccone G (Jul 2014). "CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance". The Journal of Clinical Investigation. 124 (7): 3003–15. doi:10.1172/JCI73048. PMC 4071378. PMID 24911146.

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The would-be hard fork with an expanded block size limit was described by hardware manufacturer Bitmain in June 2017 as a "contingency plan" should the bitcoin community decide to fork; the first implementation of the software was proposed under the name Bitcoin ABC at a conference that month. In July 2017, the Bitcoin Cash name was proposed by mining pool ViaBTC. The change, called a fork, took effect on 1 August 2017. As a result, the bitcoin ledger called the blockchain and the cryptocurrency split in two.[16]

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Bitcoin Cash (BCH) is hard fork (a community-activated update to the protocol or code) of Bitcoin that took effect on August 1st, 2017 that increased the block size to 8MB, to help the scale the underlying technology of Bitcoin.Nov 16th 2018: BCH was hard forked again and split into Bitcoin SV and Bitcoin ABC. Bitcoin ABC became the dominant chain and took over the BCH ticker as it had more hashpower and majority of the nodes in the network.

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The only known example of this design exists at the junction of US 35 and State Route 32 near Jackson, Ohio, United States (at 39.045219°N 82.612767°W). Both highways are expressways in each direction. Each highway has ramps that exit to the other highway, with right-turning traffic merging onto the second highway, but left-turning traffic coming to an at-grade intersection. Both highways end up having at-grade intersections, albeit with a grade separation of the main highway corridors.

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There is a rarely used, unnamed type of interchange using a grade-separated design, similar to the at-grade design known as a "synchronized split-phasing intersection".[7] It is somewhat like the diverging windmill except that left turn exits use left directional ramps, which, as with the diverging windmill, merge on the left. One such interchange formerly existed between Interstate 95 and I-695 north of Baltimore, which has since been replaced by a four-level stack. There are few of these "synchronized split-phasing" interchanges, including one in Birmingham, Alabama between I-65 and I-20/I-59, locally called Malfunction Junction (33.521505°N 86.826564°W). Another is located in Riyadh, Saudi Arabia between the Eastern Ring Road and the Southern Ring Road (24.630868°N 46.803215°E). A variation of this type exists in Grand Rapids, Michigan between Interstate 196 and US 131, where only the opposing carriageways of US 131 cross over each other, while the carriageways for I-196 do not cross over, but pass through the interchange on different levels. Another variation of this type exists in Charlotte, North Carolina between I-77 and I-85, where only the opposing carriageways of I-77 cross over each other; there are loop ramps from I-77 northbound to I-85 southbound and also from I-77 southbound to I-85 northbound.

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A stack interchange is a four-way interchange whereby a semi-directional left turn and a directional right turn are both available. Usually access to both turns is provided simultaneously by a single offramp. Assuming right-handed driving, in order to cross over incoming traffic and go left, vehicles first exit onto an off-ramp from the rightmost lane. After demerging from right-turning traffic, they complete their left turn by crossing both highways on a flyover ramp or underpass. The penultimate step is a merge with the right-turn on-ramp traffic from the opposite quadrant of the interchange. Finally an onramp merges both streams of incoming traffic into the left-bound highway. As there is only one offramp and one onramp (in that respective order), stacks do not suffer from the problem of weaving, and due to the semi-directional flyover ramps and directional ramps, they are generally safe and efficient at handling high traffic volumes in all directions.

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The would-be hard fork with an expanded block size limit was described by hardware manufacturer Bitmain in June 2017 as a "contingency plan" should the bitcoin community decide to fork; the first implementation of the software was proposed under the name Bitcoin ABC at a conference that month. In July 2017, the Bitcoin Cash name was proposed by mining pool ViaBTC. The change, called a fork, took effect on 1 August 2017. As a result, the bitcoin ledger called the blockchain and the cryptocurrency split in two.[16] 

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It features directional ramps (no loops, or weaving right to turn left) and can use multi-lane ramps in comparatively little space. Some designs have two ramps and the "inside" thru road (on the same side as the freeway that ends) crossing each other at a three-level bridge. The disadvantage is that traffic of the terminating road enters and leaves on the passing lane.[8] The T interchange is preferred to a trumpet interchange because a trumpet requires a loop ramp by which speeds can be reduced, but flyover ramps can handle much faster speeds.
A half-clover interchange is essentially half a cloverleaf interchange, constructed to connect in just three directions instead of four. These are rarely used due to the traffic weaving that they cause and the large amount of land that they consume, but they can be built in areas where the connecting ramp along the loop of a trumpet interchange is not feasible due to building developments or physical limitations. Half-clovers are designed to be readily upgraded to full cloverleaves if the terminating highway is ever extended past the through highway. Numerous half-clovers exist along I-90/I-94 in the Chicago, Illinois area.

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In the field of road transport, an interchange is a road junction that uses grade separation, and typically one or more ramps, to permit traffic on at least one highway to pass through the junction without interruption from other crossing traffic streams. It differs from a standard intersection, where roads cross at grade. Interchanges are almost always used when at least one road is a controlled-access highway (freeway or motorway) or a limited-access divided highway (expressway), though they are sometimes used at junctions between surface streets.
In the field of road transport, an interchange is a road junction that uses grade separation, and typically one or more ramps, to permit traffic on at least one highway to pass through the junction without interruption from other crossing traffic streams. It differs from a standard intersection, where roads cross at grade. Interchanges are almost always used when at least one road is a controlled-access highway (freeway or motorway) or a limited-access divided highway (expressway), though they are sometimes used at junctions between surface streets.

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A similar concept involves a partial cloverleaf interchange ("parclo") type A4, since that type of junction involves turning traffic off the freeway turning left onto the arterial, though the arterial itself exits with loop ramps eliminating left-hand turns onto the freeway, as well as to not invoke at-grade crossings for left turns onto the freeway.

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There is a rarely used, unnamed type of interchange using a grade-separated design, similar to the at-grade design known as a "synchronized split-phasing intersection".[7] It is somewhat like the diverging windmill except that left turn exits use left directional ramps, which, as with the diverging windmill, merge on the left. One such interchange formerly existed between Interstate 95 and I-695 north of Baltimore, which has since been replaced by a four-level stack. There are few of these "synchronized split-phasing" interchanges, including one in Birmingham, Alabama between I-65 and I-20/I-59, locally called Malfunction Junction (33.521505°N 86.826564°W). Another is located in Riyadh, Saudi Arabia between the Eastern Ring Road and the Southern Ring Road (24.630868°N 46.803215°E). A variation of this type exists in Grand Rapids, Michigan between Interstate 196 and US 131, where only the opposing carriageways of US 131 cross over each other, while the carriageways for I-196 do not cross over, but pass through the interchange on different levels. Another variation of this type exists in Charlotte, North Carolina between I-77 and I-85, where only the opposing carriageways of I-77 cross over each other; there are loop ramps from I-77 northbound to I-85 southbound and also from I-77 southbound to I-85 northbound.

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Like a directional T interchange, a semi-directional T interchange uses flyover (overpass) or underpass ramps in all directions at a three-way interchange. However, in a semi-directional T some of the splits and merges are switched to avoid ramps to and from the passing lane, eliminating the major disadvantage of the directional T. Semi-directional T interchanges are generally safe and efficient, though being three-level interchanges they do require more land and are costlier than trumpet interchanges. Semi-directional T interchanges are built as two or three-level stacks. Three-level stacks may use an overpass and underpass at a single point. Two-level stacks have a longer bridge or two shorter bridges on the same roadway.
High concentrations of Cripto are found in both the trophoblast and inner cell mass, along the primitive streak as the second epithelial-mesenchymal transformation event occurs to form the mesoderm, and in the myocardium of the developing heart. Though no specific defect has been formally associated with mutations in Cripto, in vitro studies that disrupt gene function at various times during development have provided glimpses of possible malformations. For example, inactivation of Cripto during gastrulation disrupted the migration of newly formed mesenchymal mesoderm cells, resulting in the accumulation of cells around the primitive streak and eventual embryonic death.[12] Other results of Cripto disruption include the lack of posterior structures.[13][14] and a block on the differentiation of cardiac myocyte,.[15] both of which lead to embryonic death.

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Central to the appeal and function of Bitcoin is the blockchain technology it uses to store an online ledger of all the transactions that have ever been conducted using bitcoins, providing a data structure for this ledger that is exposed to a limited threat from hackers and can be copied across all computers running Bitcoin software. Every new block generated must be verified by the ledgers of each user on the market, making it almost impossible to forge transaction histories. Many experts see this blockchain as having important uses in technologies such as online voting and crowdfunding, and major financial institutions such as JPMorgan Chase see potential in cryptocurrencies to lower transaction costs by making payment processing more efficient. However, because cryptocurrencies are virtual and do not have a central repository, a digital cryptocurrency balance can be wiped out by a computer crash if a backup copy of the holdings does not exist, or if somebody simply loses their private keys. At the same time, there is no central authority, government, or corporation that has access to your funds or your personal information. 

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In the field of road transport, an interchange is a road junction that uses grade separation, and typically one or more ramps, to permit traffic on at least one highway to pass through the junction without interruption from other crossing traffic streams. It differs from a standard intersection, where roads cross at grade. Interchanges are almost always used when at least one road is a controlled-access highway (freeway or motorway) or a limited-access divided highway (expressway), though they are sometimes used at junctions between surface streets.

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